Weiyue Wang

Postdoctoral Research Fellow @ UTHealth Houston, M.D. from Fudan University.

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My name is Weiyue Wang (王炜越). I am currently a postdoctoral research fellow at the Center for Cardiovascular Genetics, The University of Texas Health Science Center at Houston (UTHealth Houston).

I received my medical degree from Fudan University in 2022 and started my research career at Mayo Clinic where I utilized CRISPR-Cas9 to screen modifier genes for dilated cardiomyopathy caused by truncating variants in the TTN gene (TTNtv) in zebrafish models. At UTHealth, my focus has shifted toward uncovering the molecular mechanisms behind hereditary cardiomyopathies primarily through mouse models. My recent work, published in JCI Insight, revealed that in desmoplakin cardiomyopathy, both nuclear and mitochondrial DNA are released into the cytosol, activating DNA damage response pathways, including the cGAS-STING1 pathway. Other ongoing projects include investigating the role of nicotinamide mononucleotide (NMN) in cardiovascular aging, characterizing chromosomal changes in LMNA-related cardiomyopathy, etc.

Throughout my academic journey, I have published multiple research ariticles in the field of cardiovascular sciences. I am deeply passionate about developing genetic tools to treat cardiovascular diseases. My long-term goal is to become a physician-scientist committed to advancing care for patients with inherited heart diseases.

selected publications

  1. JCI Insight
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    Cardiac Myocyte Cytosolic Self-DNA Contributes to the Pathogenesis of Desmoplakin-Cardiomyopathy
    Weiyue Wang, Benjamin Cathcart, Quoc D Nguyen, and 6 more authors
    JCI insight, 2025
  2. JMCC
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    Deregulated nutrient response in ttntv cardiomyopathy can be repaired via Erk inhibition for cardioprotective effects
    Feixiang Yan, Weiyue Wang, Maryam Moossavi, and 3 more authors
    Journal of Molecular and Cellular Cardiology, 2025